| Synthesis and Crystal Structure of 3,3,6,6-Tetramethyl-N-hydroxy-9-ethyl-1,8-dioxo-1,2,3,4,5,6,7,8,9,10-decahydroacridine |
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| 作者姓名： | TU Shu-Jianga② WANG Qiana ZOU Xianga b SHI Fenga MIAO Chun-Baoa FANG Fanga XU Jia-Ninga a |
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| 作者单位： | TU Shu-Jianga② WANG Qiana ZOU Xianga，b SHI Fenga MIAO Chun-Baoa FANG Fanga XU Jia-Ninga a(Department of Chemistry，Xuzhou Normal University，Key Laboratory of Biotechnology on Medical Plant，Xuzhou，Jiangsu 221116，China) b (Lianyungang Teacher's College，Lianyungang，Jiangsu 222000，China) |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China (No. 20372057)，the Open Foundation of
Key Laboratory of Organic Synthesis of Jiangsu Province，College of Chemistry and Chemical Engineering，Suzhou
University (No. S8109111) and Key Lab of Biotechnology for Medicinal Plants of Jiangsu Province (No. 01AXL 14) |
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| 摘 要： | 1 INTRODUCTION 1,4-Dihydropyridines (1,4-DHPs) are well-knowncompounds because of their pharmacological pro-perty as calcium channel modulators1, . The che- 2]mical modifications, such as the introduction of dif-ferent substituents3, or heteroatoms5], of the DHP 4]ring have allowed the expansion of researches onthe structure-activity relationship to gain new in-sights into the molecular interactions at the receptorlevel. In fact, it is well established th…
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| 关 键 词： | 合成方法 晶体结构 微波放射技术 N-羟基多聚吖啶二酮 化学结构 化学性质 药理学 |
Synthesis and Crystal Structure of 3,3,6,6-Tetramethyl-N-hydroxy-9-ethyl-1,8-dioxo-1,2,3,4,5,6,7,8,9,10-decahydroacridine |
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| TU Shu-Jiang,WANG Qian,ZOU Xiang,SHI Feng,MIAO Chun-Bao,FANG Fang,XU Jia-ning.Synthesis and Crystal Structure of 3,3,6,6-Tetramethyl-N-hydroxy-9-ethyl-1,8-dioxo-1,2,3,4,5,6,7,8,9,10-decahydroacridine[J].Chinese Journal of Structural Chemistry,2005,24(3):255-258. |
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| Authors: | TU Shu-Jiang WANG Qian ZOU Xiang SHI Feng MIAO Chun-Bao FANG Fang XU Jia-ning |
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| Abstract: | The title compound (C19H29NO4) has been synthesized by the reaction of propaldehyde with dimedone and hydroxylamine hydrochloride in glycol under microwave irradiation, and its structure was determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/c with a = 12.533(1), b = 13.184(2), c = 11.883(2)(A), ц = 109.06(1)°, V = 1856.0(5)(A)3, Mr = 335.43, Z = 4, Dc = 1.201 g/cm3, λ = 0.71073 (A), ц(MoKаа = 0.083 mm-1 and F(000) = 728. The structure was refined to R = 0.0488 and Wr = 0.1456 for 2306 observed reflections with I > 2б(I). X-ray analysis reveals that the pyridine ring adopts a boat conformation, while two cyclohexanone rings have envelope conformations. |
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| Keywords: | microwave irradiation N-hydroxylpolyhydroacridinedione crystal structure |
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