Synthesis,Characterisation and Biological Activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate |
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| Authors: | Thahira B S A Ravoof K A Crouse M Ibrahim M Tahir R Rosli David J Watkin Fiona N F How |
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| Institution: | (1) Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, UPM Serdang, 43400 Selangor, Malaysia;(2) Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, 43400 Selangor, Malaysia;(3) Chemistry Research Laboratory, Department of Chemistry, Oxford University, Mansfield Road, OX13TA Oxford, UK |
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| Abstract: | Abstract A new tridentate nitrogen–sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel
dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical
and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized
in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) ?, b = 9.3832 (2) ?, c = 18.0352 (4) ?, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human
breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen
receptor). |
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