Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungus Aspergillus fumigatus |
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Authors: | Fazuo Wang Weiming Zhu |
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Institution: | Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, PR China |
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Abstract: | Seven new prenylated indole diketopiperazine alkaloids, including compound 1, 3 spirotryprostatins C-E (2-4), 2 derivatives of fumitremorgin B (5 and 6), and 13-oxoverruculogen (7), have been isolated from the holothurian-derived fungus Aspergillus fumigatus, along with 12 known ones (8-19). The structures of the new compounds were determined on the basis of extensive spectroscopic data and amino acid analysis. All new compounds were evaluated for their cytotoxic activities on MOLT-4, A549, HL-60, and BEL-7420 cell lines by the MTT and SRB methods. |
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Keywords: | Alkaloids Marine-derived fungi Aspergillus fumigatus Structure elucidation Cytotoxicity |
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