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A convenient and regioselective oxidative bromination of electron-rich aromatic rings using potassium bromide and benzyltriphenylphosphonium peroxymonosulfate under nearly neutral reaction conditions |
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| Authors: | Hadi Adibi Abdol R Hajipour Majid Hashemi |
| Institution: | a Department of Medicinal Chemistry, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 67168-67346, Iran b Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran c Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, Wisconsin 53706-1532, USA d Research and Petroleum Engineering Center of Kermanshah (A Branch of RIPI), Kermanshah 67146-77717, Iran |
| Abstract: | Regioselective oxidative bromination of electron-rich aromatic rings has been studied using potassium bromide as a bromine source in the presence of benzyltriphenylphosphonium peroxymonosulfate as oxidant under nearly neutral reaction conditions. In most cases we obtained monobrominated derivatives regioselectively and in good to high yields without the aid of strong acids. |
| Keywords: | Activated arenes Benzyltriphenylphosphonium peroxymonosulfate Oxidative bromination Potassium bromide |
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