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A formal total synthesis of crocacin C |
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| Authors: | J.S. Yadav P. Venkatram Reddy L. Chandraiah |
| Affiliation: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | An efficient total synthesis of a potent antifungal and moderate cytotoxic agent crocacin C is described. The synthesis involves the generation of four contiguous stereogenic centres via desymmetrization of a meso bicyclic dihydrofuran using asymmetric hydroboration. |
| Keywords: | Crocacin Desymmetrization Cross-metathesis Modified Julia olefination |
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