Withaphysanolide A, a novel C-27 norwithanolide skeleton, and other cytotoxic compounds from Physalis divericata |
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Authors: | Lei Ma Mohammad Arfan Li-Hong Hu |
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Institution: | a Shanghai Institute of Materia Medica, Shanghai 201203, PR China b Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan |
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Abstract: | A novel C-27 norwithasteroid, withaphysanolide A (1) containing a pyran ring was isolated from the aerial parts of Physalis divericata. Four known withaphysalins (2-5) and five physalins (6-10) were also isolated. The structural assignment for 1 was done based on spectroscopic and single-crystal X-ray diffraction data. Logical biosynthetic pathways were postulated. Compounds 6, 7, and 10 displayed potent cytotoxic activity against HCT-116 and H460 human cancer cell lines, with IC50 values less than 2.0 μM. |
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Keywords: | Norwithanolides Physalis divericata Withaphysanolide A Cytotoxicity |
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