Enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes catalyzed by a bis(oxazoline)-Cu(II) complex |
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| Authors: | Pradeep K Singh |
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| Institution: | Department of Chemistry, Indian Institute of Technology Kanpur, 208 016, India |
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| Abstract: | The catalytic enantioselective Friedel-Crafts reaction of indole with trans-β-nitrostyrene is reported in the presence of copper triflate-bisoxazoline complexes. The reaction furnished nitroalkylated indoles in excellent yields (up to 95%) and high enantioselectivities up to an 86% ee. |
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