| 应用腙作为配体的铜催化二芳醚合成反应 |
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| 引用本文： | 刘玉华a,b 李刚a,b 杨联明,a.应用腙作为配体的铜催化二芳醚合成反应[J].中国化学,2009,27(2):423-427. |
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| 作者姓名： | 刘玉华a b 李刚a b 杨联明 a |
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| 作者单位： | a北京国家分子科学中心实验室及中国科学院化学研究所新材料实验室 ; b中国科学院研究生院 ; |
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| 摘 要： | 一种简单易得的腙，2-吡啶醛 1-苯基腙 （1），能够作为有效配体，极大地促进碘化铜催化的芳基溴与酚的C–O偶联反应。该偶联反应条件温和（二氧六环为溶剂、磷酸钾为碱、90–100 0C 的反应温度），适用于各种芳基溴（电中性、贫电子和富电子）和酚（电中性和富电子）的底物，能够相容一些碱敏感官能团如酯基、醛基和羰基等。
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| 关 键 词： | 铜催化交叉偶联反应 腙类配体 二芳醚合成 |
| 收稿时间： | 2008-7-17 |
| 修稿时间： | 2008-9-19 |
Cu(I)‐catalyzed Synthesis of Diaryl Ether Using a Simple Hydrazone as Promoter |
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| Yuhua LIU,Gang LI,Lianming YANG.Cu(I)‐catalyzed Synthesis of Diaryl Ether Using a Simple Hydrazone as Promoter[J].Chinese Journal of Chemistry,2009,27(2):423-427. |
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| Authors: | Yuhua LIU Gang LI Lianming YANG |
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| Institution: | 1. Beijing National Laboratory for Molecular Sciences (BNLMS) & Laboratory of New Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China;2. Graduate School of Chinese Academy of Sciences, Beijing 100049, China;3. Tel.: 0086‐010‐62565609;4. Fax: 0086‐010‐62559373 |
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| Abstract: | A simple hydrazone‐type ligand, 2‐pyridinecarboxaldehyde phenylhydrazone 1 , was found to significantly promote the Cu(I)‐catalyzed coupling reaction between aryl bromides and phenols. This cross‐coupling reaction occurred in dioxane in 90–100 °C in the presence of K3PO4 as base, with a broader substrate scope including electron‐poor, ‐neutral or ‐rich aryl bromides as well as a high tolerance of base‐sensitive functionalities such as ester, aldehyde and ketone. |
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| Keywords: | copper‐catalyzed cross‐coupling hydrazone‐type ligand diaryl ether synthesis |
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