Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines |
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| Authors: | Pepe Antonella Pamment Michael Georg Gunda I Malhotra Sanjay V |
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| Institution: | Laboratory of Synthetic Chemistry, SAIC-Frederick, Inc., National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, Maryland 21702, USA. |
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| Abstract: | Monocyclic as well as fused bicyclic systems with a nitrogen 10 atom at the bridgehead, including indolizidines and quinolizidines, can be prepared in four steps from N-Boc β-lactams. These easily prepared, highly robust, and flexible building blocks allow the incorporation of chirality and structural diversity, rendering the method feasible for diversity- as well as target-oriented synthesis. |
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