Insights on the Modulation of SIRT5 Activity: A Challenging Balance |
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| Authors: | Matteo Mori Giulia Cazzaniga Fiorella Meneghetti Stefania Villa Arianna Gelain |
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| Affiliation: | Department of Pharmaceutical Sciences, University of Milan, Via L. Mangiagalli 25, 20133 Milano, Italy; (M.M.); (G.C.); (F.M.); (A.G.) |
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| Abstract: | ![]()
SIRT5 is a member of the Sirtuin family, a class of deacetylating enzymes consisting of seven isoforms, involved in the regulation of several processes, including gene expression, metabolism, stress response, and aging. Considering that the anomalous activity of SIRT5 is linked to many pathological conditions, we present herein an overview of the most interesting modulators, with the aim of contributing to further development in this field. |
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| Keywords: | Sirtuin 5 HDACs activators inhibitors natural compounds small molecules |
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