Preparation of alpha-elastin nanoparticles by gamma irradiation |
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Authors: | Mari Fujimoto Kouji Okamoto Masakazu Furuta |
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Institution: | aDepartment of Biological Science, Graduate school of Science, Osaka Prefecture University, 1-2 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan;bDepartment of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Fukuoka 820-8502, Japan |
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Abstract: | Nanoparticles were prepared by utilizing the thermosensitive aggregation of alpha-elastin and gamma ray crosslinking. Three different heating process, “Slow heating”, “Fast heating”, and “Heat shock”, were applied for the aggregation of the alpha-elastin and examined to yield nanoparticles by gamma rays crosslinking. As a result, only “Slow heating” process yielded nanoparticles with diameters of about ca. 300 nm above cloud point (CP) and about ca. 100 nm below CP, and a narrow size distribution above 1.0 mg/ml concentration (exclude 1.0 mg/ml). |
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Keywords: | Alpha-elastin Nanoparticle Gamma ray Crosslink |
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