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A new chemical access for 3′-acetyl-4′-hydroxychalcones using borontrifluoride-etherate via a regioselective Claisen-Schmidt condensation and its application in the synthesis of chalcone hybrids |
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| Authors: | T. Narender K. VenkateswarluB. Vishnu Nayak S. Sarkar |
| Affiliation: | a Medicinal and Process Chemistry Division, Central Drug Research Institute (CSIR), Lucknow 226 001, UP, India b National Institute of Pharmaceutical Education and Research, Raibareli, UP, India |
| Abstract: | A new chemical access has been developed for the synthesis of 3′-acetyl-4′-hydroxychalcones from 1-(5-acetyl-2-hydroxy-phenyl)-ethanone and various substituted benzaldehydes via a regioselective Claisen-Schmidt condensation using borontrifluoride-etherate (BF3·OEt2) at room temperature, in good to excellent yields within 12-24 h. Application of this methodology has also been demonstrated in the synthesis of chalcone hybrids. |
| Keywords: | Borontrifluoride-etherate Chalcone hybrids Regioselective Claisen-Schmidt condensation |
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