Advantages of NIR radiation use for optical determination of skin horny layer thickness with embedded TiO2 nanoparticles during tape stripping procedure |
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| Authors: | A P Popov A V Priezzhev J Lademann R Myllylä |
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| Institution: | (1) Physics Department, Moscow State University, Leninskie gory, Moscow, 119992, Russia;(2) Department of Technology, Optoelectronics and Measurement Techniques Laboratory, University of Oulu and Infotech Oulu, P.O. BOX 4500, 90014 Oulu, Finland;(3) Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Medical Faculty Charité, Humboldt University Berlin, D-10117 Berlin, Germany |
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| Abstract: | The tape stripping technique is an experimental method frequently used for reconstruction of the in-depth distribution of various topically administered substances within the horny layer of human skin, e.g., compounds contained in sunscreens. Titanium dioxide (TiO2) nanoparticles (25–200 nm in diameter) are one such compound. Optical techniques which apply blue light are found to be suitable for reconstruction. However, the presence of particles affects the light propagation within the skin and therefore causes incorrect determination of strip thickness, leading to an improper reconstructed distribution of nanoparticle concentration revealed from the experimental data. This study evaluates the errors emerging from the use of blue (400 nm) and NIR (800 nm) radiation and finds the use of longer wavelength light more advantageous. Particles of different diameters are considered, and it is revealed that the application of small particles (25–60 nm) results in the lowest rate of error. |
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