若干有机合成反应的构象效应

通过分析竞争反应的过渡态在构象上能量的高低,探讨构象效应(立体电子效应和位阻效应)对一些有机反应的立体性的影响;而立体电子效应和位阻效应与反应机制,反应物的结构-构象和反应条件等都有关系,最终能影响反应产物的立体结构。阐明其中的缘由可有助于正确预测产物的结构及选择可行的合成线路。

Conformational effect in some organic reactions

In this paper, the impact of conformational effect (including stereoelectronic effect anil steric effect)on the stereoselectivity in some organic reactions were discussed by estimating the energy difference between the intermediates of the competing reaction routes. Stereoelectronic effect and steric effect played a more or less important roles respectively in affecting the stereochemistry of the reactions because of different reaction mechanisms, conformational structures of the reactants and the reaction conditions. Revealing such relationship would be helpful in correctly predicting the structure of the products and selecting a more practicable synthetic route.