咪唑钴啉酯的合成及钴-氮键稳定性的研究

合成了维生素B~1~2(VB~1~2)模型分子-单腈N-甲基3-咪唑基钴啉酯高氯酸盐8。通过8在不同pH缓冲溶液中的UV-Vis谱,计算了Co-N键的平衡常数,独立配位体N-甲基咪唑与咕啉环中心钴原子配位键的键强与自身键连配位体的配位键强要弱。

Synthesis of imidazole-cobyrinate and studies of stability of Co-N bond

VB~1~2 model molecule, cyano-N-methyl-3-imidazolyl cobyrinate perchlorat 8 was synthesized from the vitamin B~1~2. 8 was treated with acidic buffers in methanol to give compounds 9 and 10. UV-Vis spectra were determined in buffers of different pH values and equilibrium constants of Co-N bonds were calculated. The strength of coordination valence between the central Co atom of cobyrin ring with the N atom of isolated N-methylimidazole ligand is weaker than that of ligand linked with cobyrin cycle.