Microwave synthesis,characterization and antimicrobial study of new pyrazolyl-oxopropyl-quinazolin-4(3H)-one derivatives |
| |
| Authors: | Jignesh P Raval Krunal G Desai Kishor R Desai |
| |
| Institution: | 1. Department of Pharmaceutical Chemistry, Ashok & Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar 388121, Anand, Gujarat, India;2. Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat 395001, Gujarat, India;3. Director, C.G. Bhakta Institute of Biotechnology, Bardoli-Mahuva Road, Surat (East) 395007, Gujarat, India |
| |
| Abstract: | Heterocyclic compounds containing pyrazolyl-oxopropyl-quinazolin-4(3H)-one are reported to possess significant biological activity. Syntheses of 6-bromo-2-(3-chloro-2-oxopropyl)-3-(4-fluorophenyl)quinazolin-4(3H)-one 2 6-bromo-3-(4-fluorophenyl)-2-(3-hydrazinyl-2-oxopropyl)quinazolin-4(3H)-one 3 and 6-bromo-2-(3-(3-(4-(1-(2-chlorophenyl)-3-methyl-1H-pyrazol-5(4H)-ylideneamino)phenyl)-5-(substituted phenyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-oxopropyl)-3-(4-fluorophenyl)quinazolin-4(3H)-one 5a–j using microwave irradiation have been described. These compounds have been characterized on the basis of the UV, IR, 1H NMR, 13C NMR, Mass and elemental analysis. Compounds have been evaluated for their antimicrobial activity. |
| |
| Keywords: | Quinazoline Pyrazolyl-quinazoline Microwave effect Antimicrobial activity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
