| A Practical Synthesis of （S）—（＋）—2—（6′—methoxyl—2—naphthyl） propionic Acid |
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| 引用本文： | HongZhu BoWANG 等.A Practical Synthesis of （S）—（＋）—2—（6′—methoxyl—2—naphthyl） propionic Acid[J].中国化学快报,2002,13(6):505-508. |
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| 作者姓名： | HongZhu BoWANG |
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| 作者单位： | [1]DepartmentofChemistry,NorthwestUniversity,ShaanXiKeyLaboratoryofPhysico－InorganicChemistry,Xi′an710068 [2]DepartmentofChemistry,NorthwestUniversity,ShaanXiKeyLaboratoryofPhysico－InorganicChemistry,Xi′a |
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| 摘 要： | A simplified procedure for enantioselective synthesis of (S)-( )-2-(6′-methoxyl-2-naphthyl)propionic acid ((S)-( )-naproxen), starting from (6-methoxy-α-naphthyl)-1-propanone,with D-mannitol as auxiliary catalyzed by SmCl3 in one-pot is described. The yield is 87.5%(ee value 99%).
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| 关 键 词： | 合成 D－甘露糖醇 （S）－（＋）－2－（6′－甲氧基－2－萘基）丙酸 |
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