Anticancer Effects of Propolis Extracts Obtained with the Cold Separation Method on PC-3 and DU-145 Prostate Cancer Cell Lines |
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| Authors: | Marek Gogacz Jerzy Peszke Dorota Natorska-Chomicka Anna Makuch-Kocka Katarzyna Dos Santos Szewczyk |
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| Affiliation: | 1.Department of Gynecology, Medical University of Lublin, 20-090 Lublin, Poland;2.Department of Experimental Biotechnology, Decont LLC, 08-500 Ryki, Poland;3.Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, 20-090 Lublin, Poland;4.Department of Pharmacology, Medical University of Lublin, 20-093 Lublin, Poland;5.Department of Pharmaceutical Botany, Medical University of Lublin, 20-093 Lublin, Poland |
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| Abstract: | ![]()
Plant extracts are increasingly tested for their biological activity and interactions with neoplastic cells. One of such sources of biologically active substances is propolis. This product has been known for thousands of years and is widely used in alternative, folk medicine. Articles describing its effects on the metabolism and cell signaling pathways of neoplastic cells derived from different organs are also published more and more frequently. The purpose of our study was to evaluate the biological activity of propolis extract produced with the cold separation method into hormone-dependent and hormone-independent prostate cancer cell lines. In our study, the propolis extracts showed at least an inhibitory effect on the growth of PC-3 and DU-145 neoplastic cells. Our results suggest that propolis extracts obtained with the cold separation method may be considered as promising compounds for the production of health-promoting supplements. |
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| Keywords: | prostate cancer propolis cold separation |
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