| Abstract: | The synthesis of some new potentially, nitrogenefree spasmolytics is described. Formally the benzene nucleus in some mandelic acid esters, known by their mild spasmolytic activity, is substituted for the isocamphane bicyclus by a) SeO2 oxidation of 1-(3,3-Dimethyl-2-exo-norbornyl)-ethanone (5) to the corresponding ketoaldehyde6, b) oxidation of6 to the isocamphane analogous mandelic acid4 and c) esterification of derivatives of4 with isoamylalcohol and benzylalcohol. Attemps to dehydrate the methylester7 to camphenylideneacetic acid methylester (12) by various methods failed, probably because of the ring strain.Teil der Diplomarbeit vonB. Blach, Universität Wien 1981. |
