Synthesis and rheological investigation of self‐healable deferoxamine grafted alginate hydrogel |
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| Authors: | Guanzhe Xu Yan Xiao Liang Cheng Runhua Zhou Heng Xu Yimin Chai Meidong Lang |
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| Institution: | 1. Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China;2. Orthopaedic Department, Shanghai 6th People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China;3. Collaborative Innovation Center for Petrochemical New Materials, Anqing, Anhui, China |
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| Abstract: | Deferoxamine grafted alginate (SA‐DFA) was successfully synthesized via amidation of sodium alginate with deferoxamine mesylate as determined by H‐NMR and elemental analysis. SA‐DFA with different graft yield was obtained by adjusting the ratio of sodium alginate and deferoxamine mesylate. It was found that aqueous solution of SA‐DFA could form hydrogel spontaneously due to hydrogen bonding interactions, which also endowed the SA‐DFA hydrogel with self‐healing capability. The healing efficiency of SA‐DFA hydrogels ranged from 53.64 to 90.16%. In addition, surface morphologies of SA‐DFA hydrogels before/after self‐healing process were demonstrated by SEM images. We anticipated that such self‐healable alginate hydrogel would be applied in the field of wound healing. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017 , 55, 856–865 |
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| Keywords: | alginate biopolymers deferoxamine hydrogen bond hydrogen bond crosslinking rheology self‐healable hydrogel self‐healing sodium alginate |
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