Synthesis and In Vitro Cytotoxic Activity of Novel Triazole‐Isoxazole Derivatives期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis and In Vitro Cytotoxic Activity of Novel Triazole‐Isoxazole Derivatives

Authors:	Zahra Najafi Mohammad Mahdavi Maliheh Safavi Mina Saeedi Heshmatollah Alinezhad Mahboobeh Pordeli Sussan Kabudanian Ardestani Abbas Shafiee Alireza Foroumadi Tahmineh Akbarzadeh

Affiliation:	1. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;2. Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences, Tehran, Iran;3. Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran;4. Faculty of Chemistry, Mazandaran University, Babolsar, Iran;5. Institute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, Iran;6. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract:	New derivatives of triazole‐isoxazole were synthesized through a four‐step reaction starting from various ethyl 4‐aryl‐2,4‐dioxobutanoate derivatives. Finally, all compounds were examined by MTT assays for cytotoxic activity in two human breast cancer cell lines (MCF‐7 and T‐47D).

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