PHOTODYNAMIC INACTIVATION OF YEAST CELLS SENSITIZED BY HEMATOPORPHYRIN |
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| Authors: | A. G. Kvello,Stenstrø m,J. Moan, ,G. Brunborg, T. Eklund |
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| Affiliation: | *Biophysics Department, Norsk Hydro's Institute for Cancer Research, Montebello, Oslo 3;Norway;‡Department of Genetics, University of Oslo, Oslo 3;Norway;§Norwegian Food Research Institute, P.O. Box 50, N-1432 Ås-NLH, Norway |
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| Abstract: | ![]()
Abstract— Yeast cells are inactivated by treatment with hematoporphyrin and light. The inactivation is mainly mediated by singlet oxygen. The quantum yield of singlet oxygen increases with increasing pH, while the efficiency of cellular inactivation decreases with increasing pH. Cells in the stationary phase are much more resistant to the treatment than cells in exponential growth. Membrane damage seems to be the main determining step in the photoinactivation. |
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