Preparation and thermal characterization of inclusion complex of Brazilian green propolis and hydroxypropyl-β-cyclodextrin |
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Authors: | Bruno Alves Rocha Marina Rezende Rodrigues Paula Carolina Pires Bueno Ana Rita de Mello Costa-Machado Mirela Mara de Oliveira Lima Leite Vaz Andresa Piacezzi Nascimento Hernane Silva Barud Andresa Aparecida Berretta-Silva |
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Institution: | 1.Laboratório de Pesquisa, Desenvolvimento & Inova??o (P, D & I),Apis Flora Industrial e Comercial LTDA,Ribeir?o Preto,Brazil;2.Instituto de Química, UNESP,Araraquara,Brazil |
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Abstract: | The propolis produced in Southeastern Brazil is known as green propolis (BGP) because of its color and the most important
plant source is Baccharis dracunculifolia. Several authors reported biological activities such as antiulcer, anti-inflammator, antimutagenic, antifungal/antibacterial,
antileishmanial/antiplasmodial for the BGP. For this reason, BGP has been extensively employed in food and beverages, thus
helping improve health and preventing diseases. Some authors related that the biological activities of BGP are mostly due
to its high levels of prenylated ρ-coumaric acids derivatives, mainly artepillin C. The inclusion complex between Brazilian
green propolis (BGP) with hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared and its characterization was investigated by
different analytical techniques (X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetry) and suggesting
that propolis was molecularly dispersed in the HP-β-CD matrix. The increasing solubility of chemical constituents was determined
using quantitation methods for total flavonoids and polyphenols. Furthermore, it was developed a method for the quantitation
and identification of the main compounds by high-performance liquid chromatography in order to evaluate the increasing water
solubility of each constituent in aqueous BGP extract (aromadendrin, isosakuranetin, and artepillin C). The antioxidant activity
was evaluated by chemical assay 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging. |
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