Use of Surfactant-Stabilized Emulsions for the Alkalimetric Determination of Indometacin |
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| Authors: | S A Kulichenko A M Shevchenko |
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| Institution: | (1) Kiev State University, ul. Vladimirskaya 64, Kiev, 01033, Ukraine |
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| Abstract: | The proton-donor properties of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid (indometacin) were studied in emulsions based on different surfactants and their mixtures. A procedure for the alkalimetric titration of indometacin with detecting the titration end-point in the presence of Cresol Red was developed using an emulsion based on dodecylpyridinium chloride. The conditions for determining indometacin in medicinal forms by pH-metric titration were selected. |
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