Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene |
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| Authors: | Kornev Alexey B Peregudov Alexander S Martynenko Vyacheslav M Balzarini Jan Hoorelbeke Bart Troshin Pavel A |
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| Institution: | IPCP RAS, Semenov Prospect 1, Chernogolovka, 141432, Russia. |
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| Abstract: | We report here a facile preparation of highly water-soluble derivatives C(70)p-C(6)H(4)(CH(2))(n)COOH](8) (n = 2, 3) starting from readily available chlorinated 70]fullerene precursors C(70)Cl(8) and C(70)Cl(10). The synthesized fullerene derivatives showed pronounced antiviral activity in vitro, particularly against human immunodeficiency virus (HIV) and influenza A virus (subtypes H1N1 and H3N2). |
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