| 天然蚕丝与丝素蛋白多孔膜的生物降解性研究 |
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| 引用本文： | 黄训亭,邵正中,陈新. 天然蚕丝与丝素蛋白多孔膜的生物降解性研究[J]. 化学学报, 2007, 65(22): 2592-2596 |
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| 作者姓名： | 黄训亭 邵正中 陈新 |
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| 作者单位： | 复旦大学高分子科学系,教育部聚合物分子工程重点实验室,上海,200433;复旦大学高分子科学系,教育部聚合物分子工程重点实验室,上海,200433;复旦大学高分子科学系,教育部聚合物分子工程重点实验室,上海,200433 |
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| 基金项目： | 国家自然科学基金 , 上海市科委资助项目 |
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| 摘 要： | 较为详细地研究了经不同条件处理的丝素蛋白多孔膜材料和天然蚕丝在蛋白酶作用下的降解性能以及降解前后材料的微观形貌和结构的变化. 结果表明, 丝素蛋白材料中不同结构(构象)的含量是影响其降解速度的一个重要因素. 对于由再生丝素溶液所制备的材料, 调控其中Silk II结构(β-折叠构象)的比例可能是控制丝素蛋白材料降解速度的有效途径.
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| 关 键 词： | 丝素蛋白多孔膜 天然蚕丝 生物降解 β-折叠 蛋白酶 |
| 收稿时间： | 2007-04-02 |
| 修稿时间： | 2007-04-02 |
Investigation on the Biodegradation Behavior of Bombyx mori Silk and Porous Regenerated Fibroin Scaffold |
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| HUANG Xun-Ting,SHAO Zheng-Zhong,CHEN Xin. Investigation on the Biodegradation Behavior of Bombyx mori Silk and Porous Regenerated Fibroin Scaffold[J]. Acta Chimica Sinica, 2007, 65(22): 2592-2596 |
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| Authors: | HUANG Xun-Ting SHAO Zheng-Zhong CHEN Xin |
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| Affiliation: | Education Ministry Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433 |
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| Abstract: | Bombyx mori silk and porous regenerated fibroin scaffold with different treatments were degraded in vitro by a protease. The quantitative, morphologic and structural changes of the materials were evaluated, showing that the conformational content was a very important factor to alter the rate of degradation in the process. Furthermore, for the regenerated fibroin materials, adjusting the content of β-sheet was an efficient method to control the rate of degradation. |
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| Keywords: | porous regenerated fibroin Bombyx mori silk biodegradation β-sheet protease |
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