Recent advancements in the synthesis of pentafluorosulfanyl (SF5)-containing heteroaromatic compounds

The unique features of the pentafluorosulfanyl (SF₅) group have made it renowned as a “super trifluoromethyl (CF₃)” group. Owing to the big success of CF₃-containing heteroaromatic compounds in medicinal chemistry, agro-chemistry and material sciences, SF₅-substituted heteroaromatic compounds have gained a lot of attention in very recent years as novel and potential candidates in these fields. However, the synthetic methodology for SF₅-substituted heteroaromatic compounds is still highly limited. This digest highlights the recent, rapid, and significant advances made in the synthesis of SF₅-heteroaromatics.