Synthesis of spiroindene-1,3-dione isothiazolines via a cascade michael/1,3-dipolar cycloaddition reaction of 1,3,4-oxathiazol-2-one and 2-arylidene-1,3-indandiones |
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| Authors: | Anjaiah Aitha Satyanarayana Yennam Manoranjan Behera Jaya Shree Anireddy |
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| Institution: | 1. Chemistry Services, GVK Biosciences Pvt. Ltd., Survey Nos.:125 (part) & 126, IDA Mallapur, Hyderabad 500076, Telangana State, India;2. Centre for Chemical Sciences & Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad 500072, Telangana, India |
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| Abstract: | The reaction of 1,3,4-oxathiazol-2-one derivative with 2-arylidene-1,3-indandione to furnish novel spiroindene-1,3-dione isothiazoline derivatives by Michael/1,3-dipolar 3+2]-cycloaddition reaction was investigated. The key 1,3-dipolar cycloaddition reaction step was examined in toluene solvent at reflux temperature to obtain mixture of two regioisomers (6a and 6b – 14a and 14b) and single isomers (15–20). The scope of this new reaction was demonstrated with many examples with high reactivity and yields. |
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| Keywords: | 1 3-Dipolar cycloaddition 1 3 4-Oxathizole-2-one Indanedione Isothiazoline Regioisomers |
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