Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice |
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| Authors: | Joel A Dietz Yan Li Lisa M Chung Brian S Yandell Cassandra L Schlamp Robert W Nickells |
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| Affiliation: | (1) Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA;(2) Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA;(3) Department of Physiology, University of Wisconsin, Madison, WI, USA |
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| Abstract: | Background Intrinsic apoptosis of neuronal somas is one aspect of neurodegenerative diseases that can be influenced by genetic background. Genes that affect this process may act as susceptibility alleles that contribute to the complex genetic nature of these diseases. Retinal ganglion cell death is a defining feature of the chronic and genetically complex neurodegenerative disease glaucoma. Previous studies using an optic nerve crush procedure in inbred mice, showed that ganglion cell resistance to crush was affected by the Mendelian-dominant inheritance of 1–2 predicted loci. To assess this further, we bred and phenotyped a large population of F2 mice derived from a resistant inbred strain (DBA/2J) and a susceptible strain (BALB/cByJ). |
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