Chemiluminescence method for the determination of mitoxantrone by the enhancement of the tris-(4,7-diphenyl-1,10-phenanthrolinedisulfonic acid)ruthenium(II)–cerium(IV) system

A new injection chemiluminescence system was used for the determination of mitoxantrone. The technique is based on the reduction effect of mitoxantrone on the tris-(4,7-diphenyl-1,10-phenanthrolinedisulfonic acid)ruthenium(II), which is produced by reaction between tris-(4,7-diphenyl-1,10-phenanthrolinedisulfonic acid)ruthenium(II) and acidic cerium(IV) solutions, and this rapid reduction produces strong chemiluminescence. The chemiluminescence intensity was so high that it is able to produce a detection limit of 1.4 × 10⁻⁸ mol L⁻¹ mitoxantrone (3σ). The relative standard deviation of 1.0 × 10⁻⁶ mol L⁻¹ mitoxantrone was 1.9% (n = 11). The method was successfully applied to the determination of mitoxantrone in pharmaceutical preparations in capsule, spiked serum and urine samples. Electronic supplementary material to this paper is available in electronic form at Electronic supplementary material. Additional figures are available online as electronic supplementary material (ESM) at . Correspondence: Lanhua Chen, Department of Chemistry, Huaibei Coal Industry Teachers’ College, Huaibei 235000, P.R. China