Neural stem cells from protein tyrosine phosphatase sigma knockout mice generate an altered neuronal phenotype in culture |
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| Authors: | David L Kirkham Laura KK Pacey Michelle M Axford Roberta Siu Daniela Rotin Laurie C Doering |
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| Affiliation: | (1) Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada;(2) Cell Biology Program, The Hospital for Sick Children and Department of Biochemistry, University of Toronto, Toronto, Ontario, M5G 1X8, Canada |
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| Abstract: | Background The LAR family Protein Tyrosine Phosphatase sigma (PTPσ) has been implicated in neuroendocrine and neuronal development, and shows strong expression in specific regions within the CNS, including the subventricular zone (SVZ). We established neural stem cell cultures, grown as neurospheres, from the SVZ of PTPσ knockout mice and sibling controls to determine if PTPσ influences the generation and the phenotype of the neuronal, astrocyte and oligodendrocyte cell lineages. |
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