Efficient stereospecific synthesis of (S,S)-3-methoxy-4-methylaminopyrrolidine |
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| Institution: | 1. Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Wannan Medical College, Wuhu, Anhui 241002, China;2. Anhui College of Traditional Chinese Medicine, Wuhu, Anhui 241000, China;3. Anhui Normal University, Wuhu, Anhui 241000, China |
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| Abstract: | Efficient stereospecific synthesis of (S,S)-3-methoxy-4-methylaminopyrrolidine, an important intermediate for a novel quinolone antitumor agent AG-7352 is presented. Starting from either d- or l-tartaric acid, a stereospecific synthesis of the chiral pyrrolidine was achieved via two SN2 displacement reactions. From the results of this synthetic study, the absolute structure of AG-7352 was chemically determined. |
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