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Evidence of asymmetric autocatalysis in the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde using chiral pyrimidyl alkanol
Institution:1. Key Laboratory for Green Chemistry Process of Ministry of Education, School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073, PR China;2. College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, PR China;1. Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China;2. The USTC-Anhui Tobacco Joint Laboratory of Chemistry and Combustion, Hefei 230066, PR China;1. Department of Physics, University of Calabria, Rende (CS) 87036, Italy;2. Institut des Nanosciences de Paris (INSP), Paris 75005, France;3. Department of Chemistry, University of Calabria, Rende (CS) 87036, Italy;4. Institute of Chemistry, Military University of Technology, Warsaw, Poland
Abstract:Kinetic analysis of the relationship between the reaction time and the yields of the product in the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde using chiral pyrimidyl alkanol proves that the reaction is autocatalytic.
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