A facile intramolecular azido/amido reductive cyclization approach: synthesis of pyrrolobenzodiazepines and their dimers期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A facile intramolecular azido/amido reductive cyclization approach: synthesis of pyrrolobenzodiazepines and their dimers

Authors:	Ahmed Kamal N. Shankaraiah K. Laxma Reddy

Affiliation:	^a Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India ^b Department of Chemistry, Kakatiya University, Warangal 506 009, AP, India

Abstract:	A new synthetic pathway has been developed for the preparation of imine-containing pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) and their dimers. Selective reduction of aromatic azides as well as aliphatic amides in a single step leading to an intramolecular reductive cyclization process by employing LiAlH₄ or LiBH₄ provides the cyclized imines.

Keywords:	Pyrrolo[2,1-c][1,4]benzodiazepines Intramolecular reductive cyclization Azides Amides LiAlH₄ LiBH₄
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