Inhibition of polyphosphoinositide breakdown and prostaglandin synthesis in rat mesangial cells by islet-activating protein |
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Authors: | J. Pfeilschifter A. Kurtz C. Bauer |
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Affiliation: | (1) Physiologisches Institut der Universität Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland |
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Abstract: | ![]() Conclusions Our results show that pertussis toxin abolished the angiotensin II-induced breakdown of PIP2 and also the increase in prostaglandin E2 synthesis in mesangial cells. It is suggested that a guanine nucleotide binding regulatory protein is somehow involved in receptor-mediated activation of phospholipase C in mesangial cells.
Islet-activating-Protein hemmt Polyphosphoinositid-Abbau und Prostaglandinsynthese in Rattenmesangialzellen |
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