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Inhibition of polyphosphoinositide breakdown and prostaglandin synthesis in rat mesangial cells by islet-activating protein
Authors:J. Pfeilschifter   A. Kurtz  C. Bauer
Affiliation:(1) Physiologisches Institut der Universität Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland
Abstract:
Conclusions Our results show that pertussis toxin abolished the angiotensin II-induced breakdown of PIP2 and also the increase in prostaglandin E2 synthesis in mesangial cells. It is suggested that a guanine nucleotide binding regulatory protein is somehow involved in receptor-mediated activation of phospholipase C in mesangial cells.
Islet-activating-Protein hemmt Polyphosphoinositid-Abbau und Prostaglandinsynthese in Rattenmesangialzellen
Keywords:
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