| Methods of calibration to optical trapping force upon non-spherical cells |
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| 作者姓名： | 喻有理 张镇西 李政 王小力 |
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| 作者单位： | The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Biomedical Engineering，Xi'an Jiaotong University，Xi'an 710049 School of Science，Xi'an Jiaotong University，Xi'an 710049，The Key Laboratory of Biomedical Information Engineering of Ministry of Education，and Institute of Biomedical Engineering，Xi'an Jiaotong University，Xi'an 710049，The Key Laboratory of Biomedical Information Engineering of Ministry of Education，and Institute of Biomedical Engineering，Xi'an Jiaotong University，Xi'an 710049，School of Science，Xi'an Jiaotong University，Xi'an 710049 |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China under Grant No. 60378018 and 60578026. |
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| 摘 要： | The dynamical equation of a trapping cell is solved to find calibration methods for the trapping force, and two methods are compared by synthetic experiment data. Results indicate that: Boltzmann distribution method (BDM) is available for the force calibration of non-spherical or anisotropic cells in arbitrary trap potential; the mean square displacement method (MSDM) is available only for a symmetric harmonic optical trap. The spatial resolution requirement of the calibration system is about a nanometer. The results agree with the reported experiments.
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