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| 应用于单分子测序的纳米微结构器件 | |
| 引用本文： | 李运涛,任鲁风,周晓光,于军,俞育德. 应用于单分子测序的纳米微结构器件[J]. 物理, 2012, 41(7): 467-471 |
| 作者姓名： | 李运涛 任鲁风 周晓光 于军 俞育德 |
| 作者单位： | 1. 中国科学院半导体研究所集成光电子学国家重点联合实验室,北京100083 中国科学院半导体研究所中国科学院北京基因组研究所生物信息获取与传感技术联合实验室,北京100083 2. 中国科学院北京基因组研究所基因组科学与信息重点实验室,北京100029 中国科学院半导体研究所中国科学院北京基因组研究所生物信息获取与传感技术联合实验室,北京100083 |
| 基金项目： | 国家自然科学基金青年基金，中国科学院科研装备研制项目 |
| 摘 要： | 基因测序技术是现代最为重要的生物医学研究手段之一,单分子测序技术作为最新一代测序技术被广泛研究,并形成了微纳制造、光电子、微流控和分子生物学等多学科的交叉探索和多种技术创新的有机结合.文章系统总结了应用于单分子测序的纳米微结构器件的原理和功能,重点阐述了零模波导器件和纳米孔器件在单分子测序中的作用以及制备工艺,从器件的角度提出了单分子测序技术所面临的挑战. |
| 关 键 词： | 单分子测序 纳米微结构器件 |
Nanostructure devices for single molecule sequencing |
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| LI Yun-Tao,REN Lu-Feng,ZHOU Xiao-Guang,YU Jun,YU Yu-De. Nanostructure devices for single molecule sequencing[J]. Physics, 2012, 41(7): 467-471 | |
| Authors: | LI Yun-Tao REN Lu-Feng ZHOU Xiao-Guang YU Jun YU Yu-De |
| Affiliation: | 1 , 3 (1 State Key Laboratory of Integrated Optoelectronics , Institute of Semiconductors , Chinese Academy of Sciences , Beiing100083 , China ) ( 2 Key Laboratory of Genome Sciences and Information , Beijing Institute of Genomics , Chinese Academy of Sciences , Beijng100029 , China ) ( 3 The Joint Laboratory of Bioinformation Acquisition and Sansing Technology , Institute of Semiconductors , Beijing Institute of Genomics , Chinese Academy of Sciences , Beijing100083 , China ) |
| Abstract: | As a most important biomedical technology , DNA sequencing , especially single molecule se- quencing , has become a research focus not only in biology but also in engineering and physics.It combines nanofabrication , optoelectronics , microfluidics , and molecular biology technologies together to develop our capability to detect the activities of single nucleotides.In this review , the nanostructure devices for single molecule sequencing are summarized.The principle and structure of zero-mode waveguides and nanopore devices are described in detail , as well as the challenges of single-molecule sequencing. |
| Keywords: | single molecule sequencing nanostructure devices |
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