Catalyst-free synthesis of coumarin-, quinolone- and pyridine-annulated oxazole derivatives |
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Authors: | KC Majumdar Sintu Ganai Raj Kumar Nandi Krishanu Ray |
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Institution: | 1. Department of Chemistry, University of Kalyani, Kalyani 741 235, West Bengal, India;2. Department of Chemical Sciences, Tezpur University, Napaam, Tezpur 784 028, India |
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Abstract: | An efficient approach for the synthesis of coumarin-, quinolone- and pyridine-annulated oxazole derivatives has been achieved by direct base-mediated intramolecular carbon–oxygen bond formation in a transition metal catalyst-free protocol. Intramolecular cyclization of o-bromoamides in DMSO in the presence of Cs2CO3 at 130 °C affords heterocycle-annulated oxazole derivatives in high yields via a nucleophilic addition of amide to form the C–O bond. |
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