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Kanamycin A 6′-pyrenylamide: a selective probe for heparin detection |
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| Authors: | Santosh V Nalage Sidhanath V Bhosale Suresh K Bhargava Sheshanath V Bhosale |
| Institution: | 1. Department of Organic Chemistry, North Maharashtra University, Jalgaon, India;2. School of Applied Sciences, RMIT University, GPO Box 2476V, Melbourne, Vic. 3001, Australia;3. Polymer and Functional Materials, Indian Institute of Chemical Technology, Hyderabad, AP 500 607, India |
| Abstract: | We have synthesized a novel derivative of kanamycin A bearing a pyrenyl fluorophore which can be used for the specific recognition of heparin in EtOH:H2O (1:3) through formation of a 2:1 complex. The receptor shows specific optical signalling for heparin, but exhibits no significant changes on addition of various other biological molecules. |
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