Use of the diphasic dialysis as a new extraction procedure in the determination of enrofloxacin and ciprofloxacin in egg |
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Authors: | M Lolo S Pedreira C Fente BI Vázquez CM Franco A Cepeda |
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Abstract: | We have developed a new method for the analysis of the fluoroquinolones enrofloxacin and ciprofloxacin in eggs using a diphasic dialysis procedure as extraction and purification method. High pressure liquid chromatography-mass spectrometry (HPLC-MS) was used for the confirmatory determination of these compounds. The method was found to be linear between 10 and 800 ng g−1 for enrofloxacin, and between 20 and 1600 ng g−1 for ciprofloxacin. The recovery percentages were in the 70-104% range for enrofloxacin, and 55-97% for ciprofloxacin. The assay described was repeatable and reproducible with a limit of quantitation of 2 and 4 ng g−1 for enrofloxacin and ciprofloxacin from egg, respectively. |
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Keywords: | Fluoroquinolone Enrofloxacin Ciprofloxacin Diphasic dialysis Egg LC-MS |
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