| 希土化合物对离体巨噬细胞的影响 |
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| 引用本文： | 温和瑞,郭国瑞,朱卫华,王金晞. 希土化合物对离体巨噬细胞的影响[J]. 无机化学学报, 1995, 11(4): 389-393 |
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| 作者姓名： | 温和瑞 郭国瑞 朱卫华 王金晞 |
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| 作者单位： | 赣南师范学院化学系，南京大学配位化学研究所，配位化学国家重点实验室 |
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| 摘 要： | 本文应用细胞培养法和单细胞阳离子测定系统研究了希土化合物以地巨噬细胞的影响，结果表明，在培养介质中ＳｍＣｌ３和Ｙｃｌ３的浓度大于１ｍｍｏｌ．ｄｍ＾－３时，有明显的细胞毒性，Ｙｃｌ３的细胞毒性大于ＳｍＣｌ３，ＳｍＣｌ３和ＹＣｌ３的细胞毒性明显大于Ｓｍ（Ａｌａ）３Ｃｌ３和Ｙ（Ａｌａ）２Ｃｌ３。希土化合物的作用使细胞（Ｃａ＾２＋ｉ）升高；毒性越大，Ｃａ＾２＋ｉ升高越甚。低浓度Ｓｍ＾３＋和Ｙ６３＋对细胞膜
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| 关 键 词： | 细胞毒性 稀土化合物 钐 钇 巨噬细胞 |
| 收稿时间： | 1994-12-21 |
EFFECT OF RARE EARTH COMPOUNDS TO ALVEOLAR MACROPHAGE IN VITRO |
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| Wen Herui,Guo Guorui,Zhu Weihua and Wang Jinxi. EFFECT OF RARE EARTH COMPOUNDS TO ALVEOLAR MACROPHAGE IN VITRO[J]. Chinese Journal of Inorganic Chemistry, 1995, 11(4): 389-393 |
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| Authors: | Wen Herui Guo Guorui Zhu Weihua Wang Jinxi |
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| Affiliation: | Wen Herui; Guo Guorui(Department of Chemistry. Gannan Teachers College. Ganzhou 341000)Zhu Weihua; Wang Jinxi(Coordination Chemistry Institute. Coordination Chemistry State Key Laboratory.Nan jing Universily. Naming 210093) |
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| Abstract: | Using cell incubation and AR-CM-MIC Canon Mcasurcmcnt System, the effect of rare earth compounds to alveolar macrophage was studied in vitro. The results arc mainly as follows: lmmol·dm-3SmCl3, or YCl3 in incubation medium has obvious cytotoxicity. The cytotoxicity of YCl3, is greater than that of SmCl3. The cytotoxicity of SmCl3 or YCl3 is greater than that of Sin(Ala)3Cl3 or Y(Ala)2Cl3. The poisonous action of rare earth compounds to alveolar macrophage leads to the increase of [Ca2+]. The greater the cytotoxicity, the greater the increase of [Ca2+]. Sm3+ and Y3+ can activate the Ca2+-ATPase of crythrocytic membrane. |
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| Keywords: | rare earth compound cytotoxicity cytoplasmic Ca2+ Ca2+-ATPase |
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