Structurally Controlled Porphyrin-Aggregation Process in Phospholipid Membranes |
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| Authors: | Victor V Borovkov Michael Anikin Kiyotaka Wasa Yoshiteru Sakata |
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| Institution: | Research Institute of Innovative Technology for the Earth (RITE), Kyoto, Japan;Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan |
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| Abstract: | Abstract— Structurally controlled aggregation course for five porphyrins (etioporphyrin EP], 5-mono- and 5,15-di- p -tol-yl]etioporphyrin TP and DTP], 5,10,15,20-tetrakis p -tol-y1]porphin TTP], and 5,10,15,20-tetrakis3,5-di- tert -bu-tylphenyl]porphin TBP]) in dipalmitoyl-phosphatidyl-choline liposomes has been monitored by fluorescence and absorption spectroscopy. While TBP shows no tendency to aggregate in liposomes, EP, TP, DTP and TTP form a porphyrin-enriched domain in membrane interior with time. The further aggregation steps within porphyrin clusters resulting in formation of stacked porphyrin aggregates have been observed for EP, TP and DTP. |
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