Diastereoselective Three Component Reaction of N‐Glyoxyloyl Camphorpyrazolidinone,Amine and Allyltributylstannane: Facile Synthesis of Homoallylic Amines |
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| Authors: | Chih‐Liang Chang Kwun‐Min Chen |
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| Institution: | Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan 116, R.O.C. |
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| Abstract: | Diastereoselective allylation of imine derived from N‐glyoxyloyl camphorpyrazolidinone and amines was treated with allyltributylstannane in the presence of triflic acid. The corresponding optically enriched homoallylic amines were obtained in reasonable to high material yields and with practical levels of stereoselectivity in 10 min at ambient temperature. |
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| Keywords: | Diastereoselective Chiral auxiliary Allylation Homoallylic amine Stereoselectivity Camphorpyrazolidinone |
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