Total Synthesis of (±)‐Glyflavanone by a Rigid Quaternary Ammonium Salt |
| |
Authors: | Yu‐Ting Fang Chia‐Ning Lin Huan‐Ting Wu Yean‐Jang Lee |
| |
Institution: | Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan, R.O.C. |
| |
Abstract: | Total synthesis of (±)‐glyflavanones and glychalcones was accomplished starting from the known 1‐(5‐hydroxy‐7‐methoxy‐2,2‐dimethyl‐2H‐chromen‐6‐yl)ethanone ( 6 ). A new approach to synthesis of flavanones, based on a high yielding N‐benzylcinchoninium salt catalyzed chromane ring forming enantio‐selective cyclization process, is described. Also, synthesis of (+)‐glyflavanone 1 , the natural enantiomer, was achieved through optical resolution of a key intermediate in racemic synthesis. |
| |
Keywords: | Enantioselectve Glyflavanones N‐benzylcinchoninium salt |
|
|