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Synthesis of 5‐Radioiodoarabinosyl Uridine Analog for Probing the HSV‐1 Thymidine Kinase Gene |
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| Authors: | Kun‐I Lin Li‐Wu Chiang Chien‐Hung Wu Shao‐Wei Chen Chung‐Shan Yu |
| Institution: | 1. Department of Nuclear Science, National Tsing‐Hua University, No. 101, Sec. 2, Guang‐Fu Road, Hsinchu 300, Taiwan, R.O.C.;2. Chang Bing Memorial Hospital, No. 6, Lu‐Gung Road, Chang‐Hua County 505, Taiwan, R.O.C. |
| Abstract: | Tumor cells transduced with herpes simplex virus thymidine kinase gene have been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facile preparation of 5‐125I] iodoarabinosyl uridine starting from commercially available uridine is reported herein. |
| Keywords: | HSV‐1 TK Cancer Arabinosyl uridine Stannane Radioiodine |