1. Department of Chemistry, Xuzhou Normal University, Xuzhou Jiangsu, 221116, China;2. The Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou 221116, China;3. School of Chemical Engineering, China University of Mining and Technology, Xuzhou Jiangsu 221008, China
Abstract:
A clean and simple synthesis procedure for benzo[f]quinolin‐3‐carbonyl urea and thiourea derivatives was developed based on the reaction between N‐arylidenenaphthalen‐2‐amine and barbituric acid or thiobarbituric acid in aqueous media catalyzed by triethylbenzylammonium chloride (TEBAC). It was interesting that the structures of products in solvent of DMSO‐d6 solution were different from those of the crystal states, which keep the enol form. The products were characterized by 1H NMR, and 13C NMR, and the crystal state was confirmed by X‐ray diffraction study of 3e . In addition, water was chosen as green solvent.
