1. Laboratoire de Chimie Organique, Faculté des Sciences Dhar Mehraz, 30000 Fès, Morocco;2. Laboratoire d'Activation Moléculaire, Faculté des Sciences, 60000 Oujda, Morocco;3. Department of Chemistry, The University of Arizona Tucson, AZ 85721 USA
Abstract:
A series of seven new 2′,3′,4′‐substituted spiroisothiochromene‐3,5′‐isoxazolidin]‐4(1H)‐ones ( 7‐13 ) has been prepared in the reaction of benzylidene(phenyl)azane oxide ( 5 ) or benzylidene(methyl)azane oxide ( 6 ) with (3Z)‐3‐(4‐substituted‐benzylidene)‐1H‐isothio‐ chromen‐4(3H)‐one ( 1‐4 ). The reaction occurs by a 1,3‐dipolar cycloaddition mechanism that leads to the regiospecific formation of various spiroisoxazolidines ( 7‐13 ).
