1. Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt;2. Department of Green Chemistry, National Research Center, Dokki, Cairo 12622, Egypt
Abstract:
2‐Acetyl‐1‐methyl‐1H‐benzimidazole reacts with dimethylformamide‐dimethyl‐acetal (DMF‐DMA) to afford the corresponding E‐1‐(1‐methyl‐1H‐benzimidazol‐2‐yl)‐3‐N,N‐dimethylaminoprop‐2‐enone. The latter compound reacts regioselectively with some nitrilimines and nitrile oxides to afford the corresponding pyrazole and isoxazole derivatives, respectively. These reaction products react with hydrazine hydrate to give the novel pyrazolo3,4‐d]pyridazine and isoxazolo3,4‐d]pyridazine derivatives, respectively.