| 新型仿生聚合物胶束用于纳米药物载体的研究 |
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| 引用本文： | 徐建平,陈伟东,计剑,沈家骢.新型仿生聚合物胶束用于纳米药物载体的研究[J].高等学校化学学报,2007,28(2):394-396. |
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| 作者姓名： | 徐建平 陈伟东 计剑 沈家骢 |
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| 作者单位： | 浙江大学高分子科学与工程学系,教育部高分子合成与功能构造重点实验室,杭州,310027 |
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| 基金项目： | 国家自然科学基金
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教育部霍英东教育基金 |
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| 摘 要： | 对两亲性聚合物进行设计和优化, 从细胞膜仿生的设计出发, 利用原子转移自由基聚合, 制备了一种以胆固醇为疏水段、以仿细胞膜磷酸胆碱基聚合物为亲水段的两亲性分子CMPC. 在对其溶液胶束自组装行为进行探索的基础上, 以水包油(O/W)溶剂挥发法制备了包含抗癌药物阿霉素(ADR)的纳米抗癌药物载体, 通过体外细胞培养, 研究了仿细胞膜两亲分子的细胞相容性, 并对抗癌纳米药物载体抗肿瘤细胞的药效进行了初步研究.
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| 关 键 词： | 聚合物胶束 细胞膜仿生 药物缓释 生物相容性 磷酸胆碱 |
| 文章编号： | 0251-0790（2007）02-0394-03 |
| 收稿时间： | 2006-08-10 |
| 修稿时间： | 2006-08-10 |
Novel Biomimetic Polymeric Micelles for Drug Delivery |
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| XU Jian-Ping,CHEN Wei-Dong,JI Jian,SHEN Jia-Cong.Novel Biomimetic Polymeric Micelles for Drug Delivery[J].Chemical Research In Chinese Universities,2007,28(2):394-396. |
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| Authors: | XU Jian-Ping CHEN Wei-Dong JI Jian SHEN Jia-Cong |
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| Institution: | Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | Novel amphiphilic polymers,cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine)(CMPC) was specially designed as the drug delivery systems.Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture.Anti-cancer drug adriamycin(ADR) was incorporated into the micelles by oil-in-water method.The release of ADR from the nanosphere continued over 7 d.The drug-loaded micelles could effectively restrain the growth of cancer cell.These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier. |
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| Keywords: | Polymeric micelles Biomimetic of cell membrane Drug sustained release Biocompatibility Phosphorylcholine |
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