Bacterial cellulose/poly(ethylene glycol) composite: characterization and first evaluation of biocompatibility |
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Authors: | Zhijiang Cai Jaehwan Kim |
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Institution: | (1) Center for EAPap Actuator, Department of Mechanical Engineering, Inha University, 253 Yonghyun-Dong, Nam-Ku, Incheon, 402-751, South Korea; |
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Abstract: | Bacterial cellulose (BC)/poly(ethylene glycol) (PEG) composite was prepared by immersing wet BC pellicle in PEG aqueous solution
followed by freeze-drying process. The product looks like a foam structure. The morphology of BC/PEG composite was examined
by scanning electron microscope (SEM) and compared with pristine BC. SEM images showed that PEG molecules was not only coated
on the BC fibrils surface but also penetrated into BC fiber networks. It has very well interconnected porous network structure
and large aspect surface. The composite was also characterized by Fourier transform infrared spectrum, X-ray diffraction,
thermogravimetric analysis (TGA) and tensile test. It was found that the presence of PEG affected the preferential orientation
of the (1`1]0 1\bar{1}0 ) plane during the drying process of BC pellicle, which in turn decrease the crystallinity of dried BC. The TGA result showed
that the thermal stability was improved from 263 to 293 °C, which might be associated with strong interaction between BC and
PEG. Tensile test results indicate that the Young’s modulus and tensile strength tend to decrease. Biocompatibility of composite
was preliminarily evaluated by cell adhesion studies using 3T3 fibroblast cells. The cells incubated with BC/PEG scaffolds
for 48 h were capable of forming cell adhesion and proliferation, which showed much better biocompatibility than the pure
BC. The prepared BC/PEG scaffolds can be used for wound dressing or tissue-engineering scaffolds. |
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